Inflammation and Depression: Improving
Therapy Response in Some Patients

What does inflammation have to do with treating depression? Maybe a lot, according to a new study that found that infliximab helped improve response to medication in depressed patients with high inflammation levels. Here’s what the researchers had to say.

FDA Issues Warning on Off-Label Use
of Sildenafil in Children

Pulmonary arterial hypertension is rare in children, but, when cases occur, the treatment is often similar to adult cases, including the use of pulmonary vasodilators. Now, the FDA is issuing a strong warning against the off-label use of sildenafil in children under the age of 17. Find out what prompted the warning and label change.

Are Anticoagulants Overused Because of
Too-Sensitive Blood Clot Screening?

Because of the risk of pulmonary emboli, use of anticoagulants is standard at most health care facilities for trauma patients and those facing orthopedic surgery. However, a new review article suggests that the therapies may be overused. Here’s why the authors say that an increasing number of the blood clots now being identified could actually be low risk. 

Daily Pill Effective for Some Men Who
Don’t Respond to PRN ED Drugs

As difficult as it is for men to get up the nerve to ask about medication for erectile dysfunction (ED), on-demand versions of phosphodiesterase type 5 inhibitors don’t work in some users, even at the highest doses. A study presented at a recent conference looked at how effective once-a-day tadalafil was in these nonresponders. Here are the results.