Peripheral arterial disease (PAD) describes a phenomenon in which circulation to the leg is diminished due to atherosclerosis, resulting in reduced blood flow and often causing pain that can be limiting to those who experience it.
According to the CDC’s Behavioral Risk Factor Surveillance System 2013, nearly 71% of adults with atherosclerotic cardiovascular disease use aspirin regularly.
Prescribing low-dose aspirin for preventing secondary cardiovascular disease is well established, but its safety and efficacy in primary prevention remains open to debate.
The FDA’s review of drug and biological products in this medication class is critical, as a brain impairment impacts between 6.5% and 7.9% of adults in the United States.