Omaha, NE—Thanks to more precise information provided by new technology, the Recommended Dietary Allowance (RDA) for vitamin D intake should decline from 800 to 400 International Units (IU) per day, suggests new research presented at ENDO 2017, the annual scientific meeting of the Endocrine Society, in Orlando. Creighton University School of Medicine–led researchers point out that liquid chromatography mass spectrometry (LC-MS/MS) can more accurately measure 25(OH)D, allowing them to reanalyze samples from a previous study. In that earlier double-blind dose-response clinical trial about a decade ago, the study team enrolled 163 healthy postmenopausal women, aged 57 through 90 years, with vitamin D insufficiency, randomizing them to one of seven vitamin D3 doses: 400, 800, 1600, 2400, 3200, 4000, 4800 IU/day, or placebo, for a year. At the time, study authors reported that 800 IU daily would meet the vitamin D intake requirement for 97.5% of the group, but they now are able to lower that with use of the new measurement tool.

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